Clenbuterol

Lab Test Result

Composition

One tablet of pharmaceutical drug Clenbuterol Dragon Pharma contains such components as:

• Clenbuterol Hydrochloride (basic biologically active substance) 0.4 mg;
• Lactose monohydrate - 70 mg;
• Microcrystalline cellulose (MCC) - 48.5 mg;
• Wheat starch - 31.48 mg;
• Povidone K 25 - 6 mg;
• Colloidal silicon dioxide - 2 mg;
• Magnesium stearate - 2 mg.

Package

Blue round tablets in sachet, covered with a shell, biconvex form.

Pharmacological Effect

The main component of the drug Clenbuterol by Dragon Pharma is selective beta2-adrenomimetic, that is, the mechanism of action of the biologically active component includes a stimulating effect on this type of receptors, which are mainly located in the bronchial tree. In response, the following cycle of secondary messengers is activated in the following sequence: Adenylate cyclase-cAMP-Protoninase A. Further, the effects of Clenbuterol extend to myosin, a component of smooth muscle fibers, which interacts with actin, and relaxes the bronchi. Thus, the problem of narrowing the lumen of the respiratory tract during the attacks of bronchial asthma is eliminated and respiratory processes are significantly facilitated.

Clenbuterol also has a secretolytic effect. In particular, the main component of this pharmaceutical preparation slows the release of inflammatory mediators and other active biological substances from mast cells, which increase bronchoconstriction. Due to these therapeutic properties, edema decreases, stagnant phenomena are eliminated in the lumen of the bronchial tree, mucociliary clearance is improved.

Separately, it should be noted the properties of Clenbuterol, which are used in sports pharmacology. The active component of this drug has anabolic properties like steroids, but it shows its effects with less force. This pharmaceutical is an active fat burner. The mechanism of this action is a slight increase in the internal temperature of the body, thereby increasing the consumption of calories. Among athletes and bodybuilders there is an opinion that an increase in temperature by 1 degree Celsius accelerates the metabolism of fats by 5 percent.

Thanks to such therapeutic effects, the stiffness of the muscular framework and the strength significantly exceed the initial readings before passing the conservative course. The body is given relief, venous and the desired appearance. Outwardly, such effects are comparable with a long-term low-calorie diet.

Pharmacodynamics and Pharmacokinetics

This drug is used orally, after which it is sufficiently full and well absorbed from the gastrointestinal tract. Clenbuterol begins to act 10-15 minutes after ingestion, and the maximum therapeutic properties appear after 2-3 hours. Metabolised components of this pharmaceutical drug are active in the liver, after which 78 percent of the metabolic products are excreted in the urine. A small amount of metabolites are eliminated with bile in the lumen of the digestive tube.

Indications for Use

• Bronchial asthma;
• Chronic obstructive pulmonary disease.

Contraindications

• Increased individual sensitivity to the components of the drug;
• Acquired or hereditary intolerance of biologically active substances in Dragon Pharma's Clenbuterol;
• Tachycardia and tachyarrhythmia;
• Thyrotoxicosis;
• Idiopathic hypertrophic subaortic stenosis of the aorta;
• Severe forms of ischemic heart disease;
• Acute period of myocardial infarction.

Conservative treatment with Clenbutrol against the background of the following pathologies should be conducted with caution, which implies therapy in special hospitals under the constant supervision of qualified medical personnel and conducting regular diagnostic tests:

• Hyperthyroidism;
• Diabetes;
• Diseases of the cardiovascular system (in particular, severe arterial hypertension, cardiomyopathy, heart disease, ischemic disease or a tendency to arrhythmias).

Side Effects

• From the nervous system - headache and dizziness, anxiety, disturbance of sleep and wakefulness in the form of insomnia, intentional tremor of fingers.
• From the cardiovascular system - tachycardia, increased blood pressure, extrasystole, cardialgia.
• Gastrointestinal tract - dryness in the oral cavity, gastralgia, nausea, leading to vomiting..
• Local and generalized allergic reactions - urticaria, skin rash, bronchospasm, angioedema.
• From other systems of organs and tissues - muscle cramps, intense face hyperemia, increased sweating, hypokalemia and, as a consequence, muscle pain.
• here is the possibility of developing the "rebound" syndrome and resistance when this pharmaceutical product is canceled.

Separately, it should be noted the development of muscle cramps, when Clenbutrol in tablets is used by athletes and bodybuilders. This side effect is due to depletion of endogenous stocks of taurine, deficiency of sodium and potassium electrolytes, and general lack of water-salt metabolism. To facilitate muscle spasms, the following dietary changes are recommended:

• The use of an abundant amount of fruits (especially bananas, since they contain a lot of potassium);
• Plentiful drink of water;
• Additional inclusion of taurine in an amount of 3-5 grams per day;
• Tableted potassium supplements daily at bedtime on an empty stomach (at least 200-400 mg).

Clenbuterol, Instructions for Use (Method and Dosage)

Clenbuterol tablets are taken orally. The dosage of this pharmaceutical preparation depends on the body weight and the body's reaction in the form of side effects or adverse effects of the drug. The average amount of the drug used for men is about 100-140 mcg, and for women 80-100 mcg per day. Reception should not begin with the optimal dosage, but accumulate it gradually to provide the maximum therapeutic effect. That is, the conservative course starts with 1 tablet a day, and then increases by 1 tablet every day.

The duration of such therapy is about 8-10 weeks on average. However, a special drug regimen is used, since Clenbuterol does not have its anabolic effects after 18 days of continuous use. Therefore, the course consists of 2 weeks of continuous admission and 2 weeks of rest in turn, until the pharmaceutical drug is over or the attending physician stops discontinuing its further use.

Overdose

The use of dosages that exceed the prescribed dosages is accompanied by:

• Arrhythmia;
• Tachycardia;
• Hypokalemia;
• Arterial hypertension;
• Tremor of extremities;
• Pain in heart.

There is no specific antidote for Clenbuterol, therefore detoxification and symptomatic therapy is used as treatment, that is, gastric lavage, administration of oral sorbents (for example, activated charcoal), use of water-salt solutions for restoring the corresponding metabolic disorders, monitoring serum potassium level and correction its proper way.

Interaction

When prescribing Dragon Pharma's Clenbuterol, the following clinical interactions of this pharmaceutical preparation should be considered:

• Antagonism with the opposite in action beta-blockers;
• Violation of intracardiac conductivity when combined with MAO inhibitors (monoamine oxidase) and Teofillin;
• A decrease in the effectiveness of hypoglycemic agents (requires a recalculation of dosages for diabetes mellitus);
• An increase in the toxicity of cardiac glycosides (significantly increases the risk of developing a pathological condition, such as arrhythmia);
• Increased self toxicity in combination with sympathetic mimetics.

Storage Conditions

Store this pharmaceutical product in a dark place, with a moderate humidity and at a temperature of no higher than 25°C. Also, Clenbuterol tablets should be out of the reach of children.

Shelf Life

3 years.

Special Instructions

The adverse effects of conservative treatment with this pharmaceutical drug include intentional tremor, dizziness, weakness, therefore, during the passage of the therapeutic course, it is necessary to abandon the performance of potentially hazardous activities requiring maximum attention concentration and reaction speed. So, for example, you should not drive a car or other means of transportation.

For Weight Loss

This drug can be used as a fat burner in sports pharmacology, since the active ingredients increase the body's internal temperature (see the explanation of the mechanism of action above).